Brassinin induces apoptosis in PC-3 human prostate cancer cells through the suppression of PI3K/Akt/mTOR/S6K1 signaling cascades.

@article{Kim2014BrassininIA,
  title={Brassinin induces apoptosis in PC-3 human prostate cancer cells through the suppression of PI3K/Akt/mTOR/S6K1 signaling cascades.},
  author={Sung-Moo Kim and Jeong Ha Park and Ki Dong Kim and Dongwoo Nam and Bum Sang Shim and Sung-Hoon Kim and Kyoo Seok Ahn and Seung-Hoon Choi and Kwang Seok Ahn},
  journal={Phytotherapy research : PTR},
  year={2014},
  volume={28 3},
  pages={423-31}
}
The oncogenic PI3K/Akt/mammalian target of rapamycin (mTOR) signaling axis and its downstream effector, the ribosomal protein S6 kinase 1 (S6K1) play a key role in mediating cell survival in various tumor cells. Here, we investigated the effects of brassinin (BSN), a phytoalexin first identified as a constituent of cabbage, on the PI3K/Akt/mTOR/S6K1… CONTINUE READING