Branching morphogenesis and antiangiogenesis candidates: tip cells lead the way

@article{Carmeliet2009BranchingMA,
  title={Branching morphogenesis and antiangiogenesis candidates: tip cells lead the way},
  author={Peter Carmeliet and Frederik De Smet and Sonja Loges and Massimiliano Mazzone},
  journal={Nature Reviews Clinical Oncology},
  year={2009},
  volume={6},
  pages={315-326}
}
From the original concepts that tumors require a vascular supply to grow and that blocking angiogenesis could suppress tumor growth, the oncology field has witnessed clinical successes of VEGF-targeted antiangiogenic medicine. The field is now facing the challenge of overcoming resistance to VEGF-targeted therapy, and therefore additional angiogenesis inhibitors are being developed. Studies on how endothelial 'tip, stalk and phalanx cells' form sprouts have identified promising candidate… CONTINUE READING