Branched dimerization of Tat peptide improves permeability to HeLa and hippocampal neuronal cells.

@article{Monreal2015BranchedDO,
  title={Branched dimerization of Tat peptide improves permeability to HeLa and hippocampal neuronal cells.},
  author={I Abrrey Monreal and Qian Liu and Katherine A Tyson and Tyler Bland and Doralyn S. Dalisay and Erin V Adams and Gary A. Wayman and Hector C. Aguilar and Jonel P. Saludes},
  journal={Chemical communications},
  year={2015},
  volume={51 25},
  pages={5463-6}
}
A dimeric branched peptide TATp-D designed as an analogue of the HIV-Tat protein transduction domain (TATp), a prototypical cell penetrating peptide (CPP), demonstrates significantly enhanced cell uptake at 0.25 to 2.5 μM. Live cell confocal laser scanning microscopy revealed that multivalency dramatically improved the permeation potency of TATp-D to HeLa and primary hippocampal neuronal cells. The observed enhanced ability of TATp-D to translocate through the membrane is highlighted by a non… CONTINUE READING
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