Branched chain fatty acids induce nitric oxide-dependent apoptosis in vascular smooth muscle cells.

@article{Idel2002BranchedCF,
  title={Branched chain fatty acids induce nitric oxide-dependent apoptosis in vascular smooth muscle cells.},
  author={Susanne Idel and Peter Ellinghaus and Christian Wolfrum and J A Nofer and Jolein Gloerich and G. A\ssmann and Friedrich Spener and Udo Seedorf},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 51},
  pages={49319-25}
}
Clinical observations in patients with peroxisomal disorders and studies employing corresponding mouse models have shown that supraphysiological concentrations of dietary branched chain fatty acids (BCFAs) are associated with a high level of toxicity, which is poorly understood at present. Here we show that phytanic and pristanic acid, two BCFAs that are metabolized in peroxisomes, promote apoptosis in cultured vascular smooth muscle cells of human, rat, and porcine origin. Under the conditions… CONTINUE READING
24 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 24 extracted citations

Similar Papers

Loading similar papers…