Branched-chain amino acids improve glucose metabolism in rats with liver cirrhosis.

@article{Nishitani2005BranchedchainAA,
  title={Branched-chain amino acids improve glucose metabolism in rats with liver cirrhosis.},
  author={Shinobu Nishitani and Kenji Takehana and Shoji Fujitani and Ichiro Sonaka},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  year={2005},
  volume={288 6},
  pages={G1292-300}
}
It is well established that impaired glucose metabolism is a frequent complication in patients with hepatic cirrhosis. We previously showed that leucine, one of the branched-chain amino acids (BCAA), promotes glucose uptake under insulin-free conditions in isolated skeletal muscle from normal rats. The aim of the present study was to evaluate the effects of BCAA on glucose metabolism in a rat model of CCl(4)-induced cirrhosis (CCl(4) rats). Oral glucose tolerance tests were performed on BCAA… CONTINUE READING