Branched-chain amino acids and muscle ammonia detoxification in cirrhosis

@article{Dam2013BranchedchainAA,
  title={Branched-chain amino acids and muscle ammonia detoxification in cirrhosis},
  author={Gitte Aar{\o}e Dam and Peter Dr Ing Ott and Niels Kristian Aagaard and Hendrik Vilstrup},
  journal={Metabolic Brain Disease},
  year={2013},
  volume={28},
  pages={217-220}
}
Branched-chain amino acids (BCAA) are used as a therapeutic nutritional supplement in patients with cirrhosis and hepatic encephalopathy (HE). During liver disease, the decreased capacity for urea synthesis and porto-systemic shunting reduce the hepatic clearance of ammonia and skeletal muscle may become the main alternative organ for ammonia detoxification. We here summarize current knowledge of muscle BCAA and ammonia metabolism with a focus on liver cirrhosis and HE. Plasma levels of BCAA… CONTINUE READING
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