Branched-chain amino acids: enzyme and substrate regulation.

  title={Branched-chain amino acids: enzyme and substrate regulation.},
  author={John T. Brosnan and Margaret E. Brosnan},
  journal={The Journal of nutrition},
  volume={136 1 Suppl},
The three branched-chain amino acids (BCAAs) are the most hydrophobic of the amino acids and play crucial roles in determining the structures of globular proteins as well as the interaction of the transmembrane domains of membranous proteins with phospholipid bilayers. However, the three BCAAs do not behave identically. In terms of protein secondary structure, valine and isoleucine exhibit a definite preference for the beta-structure, whereas leucine has a higher preference for the alpha-helix… CONTINUE READING
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