Branched-chain amino acid supplementation promotes aerobic growth of Salmonella Typhimurium under nitrosative stress conditions

@article{Park2015BranchedchainAA,
  title={Branched-chain amino acid supplementation promotes aerobic growth of Salmonella Typhimurium under nitrosative stress conditions},
  author={Yoon Mee Park and Hwa Jeong Lee and Jae-Ho Jeong and Jae Chang Kook and Hyon E Choy and Tae-Wook Hahn and Iel Soo Bang},
  journal={Archives of Microbiology},
  year={2015},
  volume={197},
  pages={1117-1127}
}
Abstract Nitric oxide (NO) inactivates iron-sulfur enzymes in bacterial amino acid biosynthetic pathways, causing amino acid auxotrophy. We demonstrate that exogenous supplementation with branched-chain amino acids (BCAA) can restore the NO resistance of hmp mutant Salmonella Typhimurium lacking principal NO-metabolizing enzyme flavohemoglobin, and of mutants further lacking iron-sulfur enzymes dihydroxy-acid dehydratase (IlvD) and isopropylmalate isomerase (LeuCD) that are essential for BCAA… CONTINUE READING

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