Branched-chain amino acid restriction in Zucker-fatty rats improves muscle insulin sensitivity by enhancing efficiency of fatty acid oxidation and acyl-glycine export

@inproceedings{White2016BranchedchainAA,
  title={Branched-chain amino acid restriction in Zucker-fatty rats improves muscle insulin sensitivity by enhancing efficiency of fatty acid oxidation and acyl-glycine export},
  author={Phillip James White and Amanda Lee Lapworth and Jie An and Lei Wang and Robert W. McGarrah and Robert A. Moffitt Johns Hopkins University David Stevens and Olga Ilkayeva and Tabitha George and Michael J. Muehlbauer and James R. Bain and Jeff K. Trimmer and Mary Julia Brosnan and Timothy P. Rolph and Christopher B. Newgard},
  booktitle={Molecular metabolism},
  year={2016}
}
OBJECTIVE A branched-chain amino acid (BCAA)-related metabolic signature is strongly associated with insulin resistance and predictive of incident diabetes and intervention outcomes. To better understand the role that this metabolite cluster plays in obesity-related metabolic dysfunction, we studied the impact of BCAA restriction in a rodent model of obesity in which BCAA metabolism is perturbed in ways that mirror the human condition. METHODS Zucker-lean rats (ZLR) and Zucker-fatty rats (ZFR… CONTINUE READING
Highly Cited
This paper has 155 citations. REVIEW CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 26 extracted citations

Branched-Chain Amino Acids and Brain Metabolism

Neurochemical Research • 2017
View 3 Excerpts
Highly Influenced

155 Citations

0501002016201720182019
Citations per Year
Semantic Scholar estimates that this publication has 155 citations based on the available data.

See our FAQ for additional information.

References

Publications referenced by this paper.
Showing 1-10 of 43 references

Metabolite profiles and the risk of developing diabetes

Nature Medicine • 2011
View 5 Excerpts
Highly Influenced

Plasma amino acid levels and insulin secretion in obesity.

The New England journal of medicine • 1969
View 4 Excerpts
Highly Influenced

A branched-chain amino acid metabolite drives vascular fatty acid transport and causes insulin resistance

C. Jang, S. F. Oh, +4 authors M.C
Nature Medicine • 2016
View 1 Excerpt

Similar Papers

Loading similar papers…