Branched-chain alpha-keto acid dehydrogenase complex in rat skeletal muscle: regulation of the activity and gene expression by nutrition and physical exercise.

@article{Shimomura1995BranchedchainAA,
  title={Branched-chain alpha-keto acid dehydrogenase complex in rat skeletal muscle: regulation of the activity and gene expression by nutrition and physical exercise.},
  author={Yoshiharu Shimomura and Hiroyuki Fujii and Motoyoshi Suzuki and Taro Murakami and Noriaki Fujitsuka and Naoya Nakai},
  journal={The Journal of nutrition},
  year={1995},
  volume={125 6 Suppl},
  pages={1762S-1765S}
}
Branched-chain alpha-keto acid dehydrogenase complex is the rate-limiting enzyme in the catabolism of branched-chain amino acids in skeletal muscle. It is suggested that activation of this enzyme in the muscle during exercise plays an important role in the increased oxidation of branched-chain amino acids in the muscle. Evidence suggests that branched-chain alpha-keto acids, the substrates for the enzyme, regulate the activity state of the enzyme in the muscle during exercise through… CONTINUE READING
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