Branched Chain Fatty Acids Reduce the Incidence of Necrotizing Enterocolitis and Alter Gastrointestinal Microbial Ecology in a Neonatal Rat Model

@inproceedings{RanRessler2011BranchedCF,
  title={Branched Chain Fatty Acids Reduce the Incidence of Necrotizing Enterocolitis and Alter Gastrointestinal Microbial Ecology in a Neonatal Rat Model},
  author={Rinat Rivka Ran-Ressler and Ludmila Khailova and Kelly M. Arganbright and Camille K. Adkins-Rieck and Zeina E. Jouni and Omry Koren and Ruth E. Ley and James Thomas Brenna and Bohuslav Dvoř{\'a}k},
  booktitle={PloS one},
  year={2011}
}
INTRODUCTION Branched chain fatty acids (BCFA) are found in the normal term human newborn's gut, deposited as major components of vernix caseosa ingested during late fetal life. We tested the hypothesis that premature infants' lack of exposure to gastrointestinal (GI) BCFA is associated with their microbiota and risk for necrotizing enterocolitis (NEC) using a neonatal rat model. METHODS Pups were collected one day before scheduled birth. The pups were exposed to asphyxia and cold stress to… CONTINUE READING
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