Branched-Chain Amino Acids and Brain Metabolism

@article{Sperringer2017BranchedChainAA,
  title={Branched-Chain Amino Acids and Brain Metabolism},
  author={Justin E. Sperringer and Adele K. Addington and Susan M. Hutson},
  journal={Neurochemical Research},
  year={2017},
  volume={42},
  pages={1697-1709}
}
This review aims to provide a historical reference of branched-chain amino acid (BCAA) metabolism and provide a link between peripheral and central nervous system (CNS) metabolism of BCAAs. Leucine, isoleucine, and valine (Leu, Ile, and Val) are unlike most other essential amino acids (AA), being transaminated initially in extrahepatic tissues, and requiring interorgan or intertissue shuttling for complete catabolism. Within the periphery, BCAAs are essential AAs and are required for protein… CONTINUE READING
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