Brainstem mediation of prefrontal stimulus-produced hypotension

  title={Brainstem mediation of prefrontal stimulus-produced hypotension},
  author={S G Patrick Hardy and S. M. Mack},
  journal={Experimental Brain Research},
Electrical stimulation of the prefrontal cortex (PFC) in rats produces transient hypotension. It has been suggested that this stimulus-produced hypotension (SPH) may be mediated by direct PFC projections to either the posterolateral hypothalamus or the nucleus tractus solitarius (NTS). To initially test these hypotheses, microinjections (0.5 μl) of 4% lidocaine were made into various brainstem sites, including the posterolateral hypothalamus, the PFC-NTS pathway and the NTS itself. Most… CONTINUE READING
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