• Corpus ID: 23236951

Brainstem axolemmal protein phosphorylation in vitro in hens dosed with di-1-butyl-2,2-dichlorovinyl phosphate.

@article{Huggins1999BrainstemAP,
  title={Brainstem axolemmal protein phosphorylation in vitro in hens dosed with di-1-butyl-2,2-dichlorovinyl phosphate.},
  author={David J. Huggins and Rudy J. Richardson},
  journal={Journal of toxicology and environmental health. Part A},
  year={1999},
  volume={56 4},
  pages={
          263-82
        }
}
Neuropathy target esterase (neurotoxic esterase, NTE), a protein thought to be involved in the production of organophosphorus compound-induced delayed neurotoxicity (OPIDN), has been postulated to be a component of endogenous neuronal protein phosphorylation systems. The purpose of this work was to test this hypothesis as well as to investigate further the role of endogenous protein phosphorylation in toxic neuropathies. White Leghorn hens were dosed with the neuropathic compounds di-1-butyl-2… 
BIOSENSOR DETECTION OF NEUROPATHY TARGET ESTERASE IN WHOLE BLOOD AS A BIOMARKER OF EXPOSURE TO NEUROPATHIC ORGANOPHOSPHORUS COMPOUNDS
TLDR
The results suggest that the biosensor NTE assay for whole blood could serve as a biomarker of exposure to neuropathic OP compounds as well as a predictor of OPIDN and an adjunct to its early diagnosis.
QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIPS PREDICT THE DELAYED NEUROTOXICITY POTENTIAL OF A SERIES OF O-ALKYL-O-METHYLCHLOROFORMIMINO PHENYLPHOSPHONATES
TLDR
Examination of in vivo and in vitro predictions of neuropathic potential indicate that valid predictive QSAR models may be based on the in vitro approach, and adoption of this system would result in reducing experimental animal use, lowering costs, accelerating data production, and enabling standardization of a biochemically based risk assessment of the neuropathy potential of OP compounds.
Improved Electrochemical Analysis of Neuropathy Target Esterase Activity by a Tyrosinase Carbon Paste Electrode Modified by 1-Methoxyphenazine Methosulfate
TLDR
A graphite-paste tyrosinase biosensor improved by adding 1-methoxyphenazine methosulfate as a mediator enhanced sensitivity to phenol 4-fold and long-term stability 3-fold, supporting the use of blood NTE as a biochemical marker of exposure to neuropathic OP compounds.