Brainstem Seizure Severity Regulates Forebrain Seizure Expression in the Audiogenic Kindling Model

@article{Merrill2005BrainstemSS,
  title={Brainstem Seizure Severity Regulates Forebrain Seizure Expression in the Audiogenic Kindling Model},
  author={Michelle A. Merrill and Richard Wesley Clough and Phillip C. Jobe and Ronald A. Browning},
  journal={Epilepsia},
  year={2005},
  volume={46}
}
Summary:  Purpose: Although sound‐induced (audiogenic) seizures in the genetically epilepsy‐prone rat (GEPR) initially occur independent of the forebrain, repeated audiogenic seizures recruit forebrain seizure circuits in a process referred to as audiogenic kindling. In GEPR‐3s, audiogenic kindling results in facial and forelimb (F&F) clonic seizures that are typical of forebrain seizures. However, in GEPR‐9s, audiogenic kindling produces posttonic all‐limb clonus not usually observed during… Expand
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