Brain zinc chelation by diethyldithiocarbamate increased the behavioral and mitochondrial damages in zebrafish subjected to hypoxia

@inproceedings{Braga2016BrainZC,
  title={Brain zinc chelation by diethyldithiocarbamate increased the behavioral and mitochondrial damages in zebrafish subjected to hypoxia},
  author={Marcos M Braga and Emerson S. Silva and Tarsila Barros Moraes and Gabriel Henrique Schirmbeck and Eduardo Pacheco Rico and Charles Budazewsky Pinto and Denis B Rosemberg and Carlos Severo Dutra-Filho and Renato Dutra Dias and Diogo Losch de Oliveira and Jo{\~a}o Batista T. Rocha and Diogo Onofre Souza},
  booktitle={Scientific reports},
  year={2016}
}
The increase in brain levels of chelatable zinc (Zn) in dysfunctions involving oxygen deprivation has stimulated the treatment with Zn chelators, such as diethyldithiocarbamate (DEDTC). However, DEDTC is a redox-active compound and it should be better evaluated during hypoxia. We use the hypoxia model in zebrafish to evaluate DEDTC effects. The exploratory… CONTINUE READING