Brain-wide pathway for waste clearance captured by contrast-enhanced MRI

@article{Iliff2013BrainwidePF,
  title={Brain-wide pathway for waste clearance captured by contrast-enhanced MRI},
  author={Jeffrey J Iliff and Hedok Lee and Mei Yu and Tian Feng and Jean Logan and Maiken Nedergaard and Helene Benveniste},
  journal={The Journal of clinical investigation},
  year={2013},
  volume={123 3},
  pages={1299-309}
}
The glymphatic system is a recently defined brain-wide paravascular pathway for cerebrospinal fluid (CSF) and interstitial fluid (ISF) exchange that facilitates efficient clearance of solutes and waste from the brain. CSF enters the brain along para-arterial channels to exchange with ISF, which is in turn cleared from the brain along para-venous pathways. Because soluble amyloid β clearance depends on glymphatic pathway function, we proposed that failure of this clearance system contributes to… CONTINUE READING
Highly Influential
This paper has highly influenced 18 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
Recent Discussions
This paper has been referenced on Twitter 6 times over the past 90 days. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-10 of 167 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 17 references

sheath provides a complete covering of the brain microvessels : an electron microscopic 3 D reconstruction

  • H Pollock, M Hutchings, RO Weller, ET Zhang
  • 2010

Similar Papers

Loading similar papers…