Brain white matter abnormalities and correlation with severity in amyotrophic lateral sclerosis: An atlas-based diffusion tensor imaging study

@article{Du2019BrainWM,
  title={Brain white matter abnormalities and correlation with severity in amyotrophic lateral sclerosis: An atlas-based diffusion tensor imaging study},
  author={Xiaoqiang Du and Tian-Xiu Zou and Nao-Xin Huang and Z. Zou and Hua-jun Chen},
  journal={Journal of the Neurological Sciences},
  year={2019},
  volume={405}
}
  • Xiaoqiang Du, Tian-Xiu Zou, +2 authors Hua-jun Chen
  • Published 2019
  • Medicine
  • Journal of the Neurological Sciences
  • OBJECTIVES To assess microstructural alterations in white matter (WM) in amyotrophic lateral sclerosis (ALS) using diffusion tensor imaging (DTI). METHODS DTI data were collected from 34 subjects (18 patients with ALS and 16 healthy controls). The atlas-based region of interest (ROI) analysis was conducted to assess WM microstructure in ALS by combining intra-voxel metrics, which included fractional anisotropy (FA) and mean diffusivity (MD), and an inter-voxel metric, i.e., local diffusion… CONTINUE READING
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