Brain uptake of iomazenil in cirrhotic patients: a single photon emission tomography study

  title={Brain uptake of iomazenil in cirrhotic patients: a single photon emission tomography study},
  author={Fl{\'a}vio Kapczinski and Jo{\~a}o Quevedo and H. Valerie Curran and Simon Fleminger and Brian Toone and Alice Cluckie and M. H. Lader},
  journal={Journal of Psychopharmacology},
  pages={219 - 225}
Brain uptake of 123I-iomazenil was studied in seven cirrhotic patients and eight normal controls using single photon emission computerized tomography. The highest concentration of the ligand was found in the occipital cortex, which corresponds to the brain region with the highest concentration of benzodiazepine receptors.The peak uptake was delayed in patients across all brain regions. The uptake in occipital cortex was higher in low albumin cirrhotics. Patients with low albumin also presented… 
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Psychiatric neuroimaging research in Brazil: historical overview, current challenges, and future opportunities
A brief history of psychiatric neuroimaging research in Brazil is provided, including quantitative information about the growth of this field in the country over the past 20 years, and examples of the many methodological advances that have emerged.


Quantification of central benzodiazepine receptor binding potential in the brain with 123I-iomazenil SPECT: technical and interobserver variability.
The Hoffman three-dimensional brain phantom was used to investigate linearity and reproducibility of SPECT results using different 123I activity concentrations, and the brain phantom measurements showed linearity with respect to 123I concentration and good reproducecibility.
SPECT measurement of benzodiazepine receptors in human brain with iodine-123-iomazenil: kinetic and equilibrium paradigms.
These studies demonstrated the feasibility of quantification of receptor binding with SPECT using kinetic and equilibrium methods and Iodine-125-iomazenil binding potential measured in vitro in 12 postmortem samples was found to be consistent withSPECT in vivo measurements.
Central benzodiazepine receptors in human brain: estimation of regional Bmax and KD values with positron emission tomography.
Pharmacokinetics of the SPECT benzodiazepine receptor radioligand [123I]iomazenil in human and non-human primates.
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Intravenous administration of diazepam in patients with chronic liver disease.
The EEG response and drug kinetics after intravenous infusion of diazepam at 1-0 mg/min until nystagmus, dysarthria, and moderate sedation developed, has been investigated in five normal subjects and
Elevated brain concentrations of 1,4-benzodiazepines in fulminant hepatic failure.
Brain concentrations of substances inhibiting the binding of [3H]flumazenil to its receptors are increased in some patients with hepatic encephalopathy due to fulminant hepatic failure, providing a rational basis for trials of benzodiazepine-receptor antagonists in the management of this disorder.
In vitro and in vivo evaluation of iodine-123-Ro 16-0154: a new imaging agent for SPECT investigations of benzodiazepine receptors.
The purified 123I-Ro 16-0154 was found to be stable in rat brain preparations and to be metabolized in rat liver preparations, and its pharmacologic properties were comparable to those of flumazenil.
Relationship between plasma benzodiazepine receptor ligand concentrations and severity of hepatic encephalopathy
Significant but weak linear correlation was found between the relative increase in the levels of diazepam, N‐desmethyldiazepam and total benzodiazepine receptor ligands and the severity of hepatic encephalopathy, particularly in stage 4.
Supersensitivity of benzodiazepine receptors in hepatic encephalopathy due to fulminant hepatic failure in the rat: reversal by a benzodiazepine antagonist.
The phenomena described may be attributed to a partial degeneration of nerve terminals in hepatic encephalopathy, leading to a supersensitivity of benzodiazepine receptors, which parallels the previously described denervation supers sensitivity of GABA receptors present in this animal model of fulminant hepatic failure.