Brain tumour necrosis factor-alpha modulates neurotransmitters in hypothalamic paraventricular nucleus in heart failure.

@article{Kang2009BrainTN,
  title={Brain tumour necrosis factor-alpha modulates neurotransmitters in hypothalamic paraventricular nucleus in heart failure.},
  author={Y M Kang and Rong-Li He and Limin Yang and Da-nian Qin and Anuradha Guggilam and Carrie M Elks and Ning Yan and Zheng Guo and Joseph Francis},
  journal={Cardiovascular research},
  year={2009},
  volume={83 4},
  pages={737-46}
}
AIMS Increased proinflammatory cytokines after myocardial infarction augment the progression of heart failure (HF) and are of prognostic significance. Recently, we demonstrated that increased proinflammatory cytokines in the brains of HF rats increased paraventricular nucleus (PVN) superoxide and down-regulated neuronal nitric oxide synthase (nNOS), contributing to sympathoexcitation. In this study, we explored the possible roles of brain proinflammatory cytokines and their effects on… CONTINUE READING

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