Brain tumour cells interconnect to a functional and resistant network

  title={Brain tumour cells interconnect to a functional and resistant network},
  author={Matthias Osswald and Erik Jung and Felix Sahm and Gergely M Solecki and Varun Venkataramani and Jonas Blaes and Sophie Weil and Heinz Horstmann and Benedikt Wiestler and Mustafa Syed and Lulu Huang and Miriam Ratliff and Kianush Karimian Jazi and Felix T. Kurz and Torsten Schmenger and Dieter Lemke and Miriam G{\"o}mmel and Martin Pauli and Yunxiang Liao and Peter H{\"a}ring and Stefan Pusch and Verena Herl and Christian Steinh{\"a}user and Damir Krunic and Mostafa Jarahian and Hrvoje Miletic and Anna Sophie Berghoff and Oliver Griesbeck and Georgios Kalamakis and O. V. Garaschuk and Matthias Preusser and Samuel A Weiss and Haikun Liu and Sabine Heiland and Michael Platten and Peter E Huber and Thomas Kuner and Andreas von Deimling and Wolfgang Wick and Frank Winkler},
Astrocytic brain tumours, including glioblastomas, are incurable neoplasms characterized by diffusely infiltrative growth. Here we show that many tumour cells in astrocytomas extend ultra-long membrane protrusions, and use these distinct tumour microtubes as routes for brain invasion, proliferation, and to interconnect over long distances. The resulting network allows multicellular communication through microtube-associated gap junctions. When damage to the network occurred, tumour microtubes… CONTINUE READING
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