Brain tumor mutations detected in cerebral spinal fluid.

  title={Brain tumor mutations detected in cerebral spinal fluid.},
  author={Wenying Pan and Wei Gu and Seema Nagpal and Melanie G. Hayden Gephart and Stephen R Quake},
  journal={Clinical chemistry},
  volume={61 3},
BACKGROUND Detecting tumor-derived cell-free DNA (cfDNA) in the blood of brain tumor patients is challenging, presumably owing to the blood-brain barrier. Cerebral spinal fluid (CSF) may serve as an alternative "liquid biopsy" of brain tumors by enabling measurement of circulating DNA within CSF to characterize tumor-specific mutations. Many aspects about the characteristics and detectability of tumor mutations in CSF remain undetermined. METHODS We used digital PCR and targeted amplicon… CONTINUE READING
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