Brain trauma in aged transgenic mice induces regression of established abeta deposits.

@article{Nakagawa2000BrainTI,
  title={Brain trauma in aged transgenic mice induces regression of established abeta deposits.},
  author={Yasushi Nakagawa and Lai Reed and Mamoo Nakamura and T K Mcintosh and Douglas H. Smith and Kathryn E. Saatman and Ramesh Raghupathi and James Clemens and Takaomi C Saido and Virginia M-Y Lee and John Q. Trojanowski},
  journal={Experimental neurology},
  year={2000},
  volume={163 1},
  pages={244-52}
}
Traumatic brain injury (TBI) increases susceptibility to Alzheimer's disease (AD), but it is not known if TBI affects the progression of AD. To address this question, we studied the neuropathological consequences of TBI in transgenic (TG) mice with a mutant human Abeta precursor protein (APP) mini-gene driven by a platelet-derived (PD) growth factor promoter resulting in overexpression of mutant APP (V717F), elevated brain Abeta levels, and AD-like amyloidosis. Since brain Abeta deposits first… CONTINUE READING

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