Brain tissue energy dependence of CaM kinase IV cascade activation during hypoxia in the cerebral cortex of newborn piglets.

@article{DelivoriaPapadopoulos2011BrainTE,
  title={Brain tissue energy dependence of CaM kinase IV cascade activation during hypoxia in the cerebral cortex of newborn piglets.},
  author={Mar{\'i}a Delivoria-Papadopoulos and Qazi M. Ashraf and O. P. Mishra},
  journal={Neuroscience letters},
  year={2011},
  volume={491 2},
  pages={113-7}
}
The present study aims to investigate the dependence of CaM kinase IV cascade activation during hypoxia and tests the hypothesis that hypoxia-induced tyrosine phosphorylation of CaM and CaM kinase IV, activation of CaM kinase IV and phosphorylation of CREB protein during hypoxia increases as a function of increase in cerebral tissue hypoxia as measured by decrease in tissue ATP and phosphocreatine (PCr). 3-5 days old newborn piglets were divided into normoxic (Nx, FiO₂ of 0.21 for 1h) and… CONTINUE READING