Brain targeting using novel lipid nanovectors.

  title={Brain targeting using novel lipid nanovectors.},
  author={Arnaud B{\'e}duneau and François Hindr{\'e} and Anne Clavreul and Jean-Christophe Leroux and Patrick Saulnier and J F Benoit},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  volume={126 1},
The present study shows the potential of novel nanovectors for the delivery of lipophilic radionuclides and therapeutic molecules to the brain. Lipid nanocapsules (LNC) inhibiting the P-gp pump efflux, were conjugated to OX26 monoclonal antibodies (OX26 MAb) and Fab' fragments. The OX26 MAb is directed against the transferrin receptor (TfR) highly expressed… CONTINUE READING