Brain targeting studies on buspirone hydrochloride after intranasal administration of mucoadhesive formulation in rats.

Abstract

OBJECTIVES The purpose of this study was to find out whether nasal application of buspirone could increase its bioavailability and directly transport the drug from nose to brain. METHODS A nasal formulation (Bus-chitosan) was prepared by dissolving 15.5 mg buspirone hydrochloride, 1% w/v chitosan hydrochloride and 5% w/v hydroxypropyl beta-cyclodextrin… (More)
DOI: 10.1211/jpp/61.05.0017

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