Brain swelling and death in children with cerebral malaria.

  title={Brain swelling and death in children with cerebral malaria.},
  author={Karl Seydel and Samuel D. Kampondeni and Clarissa Valim and Michael J. Potchen and Danny Milner and Francis W Muwalo and Gretchen Lano Birbeck and William Guerin Bradley and Lindsay L Fox and S. J. Glover and Colleen A. Hammond and Robert S Heyderman and Cowles A. Chilingulo and Malcolm Edward Molyneux and Terrie E. Taylor},
  journal={The New England journal of medicine},
  volume={372 12},
BACKGROUND Case fatality rates among African children with cerebral malaria remain in the range of 15 to 25%. The key pathogenetic processes and causes of death are unknown, but a combination of clinical observations and pathological findings suggests that increased brain volume leading to raised intracranial pressure may play a role. Magnetic resonance imaging (MRI) became available in Malawi in 2009, and we used it to investigate the role of brain swelling in the pathogenesis of fatal… CONTINUE READING
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