Brain structure alterations and cognitive impairment following repetitive mild head impact: An in vivo MRI and behavioral study in rat.

@article{Qin2018BrainSA,
  title={Brain structure alterations and cognitive impairment following repetitive mild head impact: An in vivo MRI and behavioral study in rat.},
  author={Yang Qin and Gai-li Li and Xian-hua Xu and Zhi-yong Sun and Jian-Wen Gu and Fabao Gao},
  journal={Behavioural brain research},
  year={2018},
  volume={340},
  pages={
          41-48
        }
}
Mild traumatic brain injury (mTBI) or concussion is a common health issue. Several people repeatedly experience head impact milder than that causing concussion. The present study aimed to confirm the effects of such repeated impact on the brain structure and cognitive abilities. Rat models were established by closed skull weight-drop injury. The animals were anesthetized, subjected to single (s)-sham, s-mTBI, repetitive (r)-sham, and r-mTBI, and recovery times were recorded. MRI, including T2… CONTINUE READING
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