Brain structure, cognition and negative symptoms in schizophrenia are associated with serum levels of polysialic acid-modified NCAM

@inproceedings{Piras2015BrainSC,
  title={Brain structure, cognition and negative symptoms in schizophrenia are associated with serum levels of polysialic acid-modified NCAM},
  author={Francesca Piras and Miriam Schiff and Constanza Chiapponi and Paola Boss{\`u} and Martina M{\"u}hlenhoff and C. Caltagirone and Rita Gerardy-Schahn and Herbert Hildebrandt and G. Spalletta},
  booktitle={Translational Psychiatry},
  year={2015}
}
The neural cell adhesion molecule (NCAM) is a glycoprotein implicated in cell–cell adhesion, neurite outgrowth and synaptic plasticity. Polysialic acid (polySia) is mainly attached to NCAM (polySia-NCAM) and has an essential role in regulating NCAM-dependent developmental processes that require plasticity, that is, cell migration, axon guidance and synapse formation. Post-mortem and genetic evidence suggests that dysregulation of polySia-NCAM is involved in schizophrenia (SZ). We enrolled 45… CONTINUE READING
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