Brain structural abnormalities in Doberman pinschers with canine compulsive disorder

@article{Ogata2013BrainSA,
  title={Brain structural abnormalities in Doberman pinschers with canine compulsive disorder},
  author={Niwako Ogata and Timothy E. Gillis and Xiaoxu Liu and Suzanne M. Cunningham and Steven B. Lowen and Bonnie Lee Adams and James Sutherland-Smith and Dionyssios Mintzopoulos and Amy C Janes and Nicholas H. Dodman and Marc J. Kaufman},
  journal={Progress in Neuro-Psychopharmacology and Biological Psychiatry},
  year={2013},
  volume={45},
  pages={1-6}
}

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References

SHOWING 1-10 OF 77 REFERENCES

Disproportionate Alterations in the Anterior and Posterior Insular Cortices in Obsessive–Compulsive Disorder

The results suggest the presence of unbalanced anterior and posterior insular volumetric abnormalities in unmedicated OCD patients and emphasize the distinct role of the insular cortex in different OC symptoms, which are proposed to influence the modulation of interoceptive processing in OCD patients with different symptoms.

Anterior insular volume is larger in patients with obsessive–compulsive disorder

Voxel-Based Morphometry Study of Gray Matter Abnormalities in Obsessive-Compulsive Disorder

Findings indicate that the frontal-subcortical circuitry is dysfunctional in OCD, and suggest that the parietal cortex may play a role in the pathophysiology of this disease.

Gray Matter Alterations in Obsessive–Compulsive Disorder: An Anatomic Likelihood Estimation Meta-Analysis

A quantitative meta-analysis of VBM studies contrasting OCD patients with healthy controls concludes that structural abnormalities within the prefrontal-basal ganglia network are involved in OCD pathophysiology.

Changes in Gray Matter Volume and White Matter Microstructure in Adolescents with Obsessive-Compulsive Disorder

Mapping structural brain alterations in obsessive-compulsive disorder.

The structural brain alterations detected in the magnetic resonance images of a large series of patients with obsessive-compulsive disorder (OCD) are described using imaging procedures that allow the evaluation of volume changes throughout the brain.

Regional Gray Matter Abnormalities in Obsessive-Compulsive Disorder: A Voxel-Based Morphometry Study

Functional and biochemical alterations of the medial frontal cortex in obsessive-compulsive disorder.

Hyperactivation of the MFC during high- vs low-conflict conditions in patients with OCD may be a compensatory response to a neuronal abnormality in the region.
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