Brain structural abnormalities in Doberman pinschers with canine compulsive disorder

  title={Brain structural abnormalities in Doberman pinschers with canine compulsive disorder},
  author={Niwako Ogata and Timothy E. Gillis and Xiaoxu Liu and Suzanne M. Cunningham and Steven B. Lowen and Bonnie Lee Adams and James Sutherland-Smith and Dionyssios Mintzopoulos and Amy C Janes and Nicholas H. Dodman and Marc J. Kaufman},
  journal={Progress in Neuro-Psychopharmacology and Biological Psychiatry},

Figures and Tables from this paper

Addressing the Complexity of Tourette's Syndrome through the Use of Animal Models

The different rationales used to develop the respective animal models are critically reviewed, to discuss the potential of the contribution of animal models to elucidate TS disease mechanisms.

Genomic Risk for Severe Canine Compulsive Disorder , a Dog Model of Human OCD

The rationale is that identifying pathways that predispose to disease severity will expand therapeutic options, and ultimately bring relief to those patients suffering the most.

An Interdisciplinary Approach for Compulsive Behavior in Dogs: A Case Report

Compulsive disorder is a debilitating condition affecting both humans and animals, characterized by intrusive thoughts and recurring out-of-place behaviors. Among them, tail chasing might represent

Metabolomic characterization of canine behavioural disorders : fearfulness and hyperactivity/impulsivity

Dogs could be used as a model to aid in gaining better understanding of human psychiatric disorders, and changes in the blood metabolic profiles of fearful and non-fearful control dogs, including increased plasma glutamine abundance in fearful dogs are identified.

Nordic OCD & Related Disorders Consortium: Rationale, design, and methods

  • D. Mataix-ColsB. Hansen J. Crowley
  • Psychology
    American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
  • 2019
The rationale, design, and methodology of NORDiC are described, including details on clinical measures and planned genomic analyses, which are geared toward answering a number of key questions regarding the biology, etiology, and treatment of OCD.

Large animals as potential models of human mental and behavioral disorders.

Data indicates many large animal disorders which can be models to examine the above human mental and behavioral disorders, including posttraumatic stress disorder, obsessive-compulsive disorder and attention deficit hyperactivity disorder.



Disproportionate Alterations in the Anterior and Posterior Insular Cortices in Obsessive–Compulsive Disorder

The results suggest the presence of unbalanced anterior and posterior insular volumetric abnormalities in unmedicated OCD patients and emphasize the distinct role of the insular cortex in different OC symptoms, which are proposed to influence the modulation of interoceptive processing in OCD patients with different symptoms.

Anterior insular volume is larger in patients with obsessive–compulsive disorder

Voxel-Based Morphometry Study of Gray Matter Abnormalities in Obsessive-Compulsive Disorder

Findings indicate that the frontal-subcortical circuitry is dysfunctional in OCD, and suggest that the parietal cortex may play a role in the pathophysiology of this disease.

Gray Matter Alterations in Obsessive–Compulsive Disorder: An Anatomic Likelihood Estimation Meta-Analysis

A quantitative meta-analysis of VBM studies contrasting OCD patients with healthy controls concludes that structural abnormalities within the prefrontal-basal ganglia network are involved in OCD pathophysiology.

Changes in Gray Matter Volume and White Matter Microstructure in Adolescents with Obsessive-Compulsive Disorder

Mapping structural brain alterations in obsessive-compulsive disorder.

The structural brain alterations detected in the magnetic resonance images of a large series of patients with obsessive-compulsive disorder (OCD) are described using imaging procedures that allow the evaluation of volume changes throughout the brain.

Regional Gray Matter Abnormalities in Obsessive-Compulsive Disorder: A Voxel-Based Morphometry Study

Functional and biochemical alterations of the medial frontal cortex in obsessive-compulsive disorder.

Hyperactivation of the MFC during high- vs low-conflict conditions in patients with OCD may be a compensatory response to a neuronal abnormality in the region.