Brain-specific conditional and time-specific inducible Tph2 knockout mice possess normal serotonergic gene expression in the absence of serotonin during adult life.

@article{Kriegebaum2010BrainspecificCA,
  title={Brain-specific conditional and time-specific inducible Tph2 knockout mice possess normal serotonergic gene expression in the absence of serotonin during adult life.},
  author={Claudia B. Kriegebaum and Ning-ning Song and L. M. Gutknecht and Ying Huang and Angelika Gertrud Schmitt and Andreas Reif and Yu-Qiang Ding and Klaus-Peter Lesch},
  journal={Neurochemistry international},
  year={2010},
  volume={57 5},
  pages={512-7}
}
Several lines of evidence implicate a dysregulation of tryptophan hydroxylase (TPH)-dependent serotonin (5-HT) synthesis in emotional behaviour and stress, and point to its relevance for the etiology and pathogenesis of various neuropsychiatric disorders. We therefore studied different animal models featuring reduced Tph2 expression to investigate the consequences of impaired brain 5-HT synthesis on neuronal development. Specifically, brain-specific conditional and time-specific inducible Tph2… CONTINUE READING