Brain reward regulated by AMPA receptor subunits in nucleus accumbens shell.

@article{Todtenkopf2006BrainRR,
  title={Brain reward regulated by AMPA receptor subunits in nucleus accumbens shell.},
  author={Mark S Todtenkopf and Aram Parsegian and Alipi V Naydenov and Rachael L. Neve and Christine Konradi and William A Carlezon},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2006},
  volume={26 45},
  pages={
          11665-9
        }
}
  • Mark S Todtenkopf, Aram Parsegian, +3 authors William A Carlezon
  • Published in
    The Journal of neuroscience…
    2006
  • Biology, Medicine
  • Drugs of abuse alter expression of AMPA-type glutamate receptor subunits (GluRs) in the nucleus accumbens (NAc), a key component of brain reward systems. The impact of this regulation on general motivational states is unclear. Here, we used herpes simplex virus vectors to examine how transient increases in the expression of GluR1 or GluR2 protein in the shell component of NAc affect the rewarding impact of electrical stimulation of the medial forebrain bundle, as reflected by intracranial self… CONTINUE READING

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