Brain responses to acute withdrawal in phenobarbital-dependent rats.

  title={Brain responses to acute withdrawal in phenobarbital-dependent rats.},
  author={Sachiko Tanaka and Yuko Okuno and Satoshi Numazawa and Tadashi Yamamoto and Seiji Shioda and Tsuyoshi Yoshida},
  journal={European journal of pharmacology},
  volume={421 2},
Heat shock proteins (HSP) such as HO-1 and HSP27 have been implicated as functioning in a protective manner against oxidative and physical stress. The objective of the current study was to determine the role of HSPs in drug-withdrawal stress induced in phenobarbital-dependent rats. Increased expression of HO-1 and HSP27 was observed in the hippocampus and the cerebral cortex of phenobarbital-withdrawn rats. Gene expression was measured by Northern and Western blot analyses and in situ… CONTINUE READING