Brain renin-angiotensin system and ouabain-induced sympathetic hyperactivity and hypertension in Wistar rats.

@article{Huang1999BrainRS,
  title={Brain renin-angiotensin system and ouabain-induced sympathetic hyperactivity and hypertension in Wistar rats.},
  author={Bing S. Huang and Frans H H Leenen Leenen},
  journal={Hypertension},
  year={1999},
  volume={34 1},
  pages={107-12}
}
In Dahl salt-sensitive rats on a high salt diet or normotensive rats with chronic central infusion of sodium, increased brain "ouabain" results in sympathetic hyperactivity and hypertension, possibly by activating the brain renin-angiotensin system. In the present study, we tested whether the hypertension caused by exogenous ouabain also depends on activation of brain renin-angiotensin system. In Wistar rats, ouabain (50 micrograms/d) was infused subcutaneously for 14 days with the use of… CONTINUE READING