Brain renin-angiotensin system and dopaminergic cell vulnerability

  title={Brain renin-angiotensin system and dopaminergic cell vulnerability},
  author={Jose L Labandeira-Garcia and Pablo Garrido-Gil and Jannette Rodr{\'i}guez-Pallares and Rita X. Valenzuela and Ana Borrajo and Ana Isabel Rodr{\'i}guez-P{\'e}rez},
  booktitle={Front. Neuroanat.},
Although the renin-angiotensin system (RAS) was classically considered as a circulating system that regulates blood pressure, many tissues are now known to have a local RAS. Angiotensin, via type 1 receptors, is a major activator of the NADPH-oxidase complex, which mediates several key events in oxidative stress (OS) and inflammatory processes involved in the pathogenesis of major aging-related diseases. Several studies have demonstrated the presence of RAS components in the basal ganglia, and… CONTINUE READING
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