Brain regional lesion burden and impaired mobility in the elderly.

  title={Brain regional lesion burden and impaired mobility in the elderly.},
  author={Nicola Moscufo and Charles R. G. Guttmann and Dominik Meier and Istvan Csapo and P Hildenbrand and Brian C. Healy and Julia A. Schmidt and Leslie Wolfson},
  journal={Neurobiology of aging},
  volume={32 4},
This study investigated the relationship of brain white matter (WM) lesions affecting specific neural networks with decreased mobility in ninety-nine healthy community-dwelling subjects ≥75 years old prospectively enrolled by age and mobility status. We assessed lesion burden in the genu, body and splenium of corpus callosum; anterior, superior and posterior corona radiata; anterior and posterior limbs of internal capsule; corticospinal tract; and superior longitudinal fasciculus. Burden in the… CONTINUE READING