Brain regional distribution of GABA(A) receptors exhibiting atypical GABA agonism: roles of receptor subunits.

@article{Halonen2009BrainRD,
  title={Brain regional distribution of GABA(A) receptors exhibiting atypical GABA agonism: roles of receptor subunits.},
  author={Lauri Halonen and Saku T. Sinkkonen and Dev Chandra and Gregg E Homanics and Esa R Korpi},
  journal={Neurochemistry international},
  year={2009},
  volume={55 6},
  pages={389-96}
}
The major inhibitory neurotransmitter in the brain, gamma-aminobutyric acid (GABA), has only partial efficacy at certain subtypes of GABA(A) receptors. To characterize these minor receptor populations in rat and mouse brains, we used autoradiographic imaging of t-butylbicyclophosphoro[(35)S]thionate ([(35)S]TBPS) binding to GABA(A) receptors in brain sections and compared the displacing capacities of 10mM GABA and 1mM 4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol (THIP), a competitive GABA… CONTINUE READING
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