Brain region-specific neurodegenerative profiles showing the relative importance of amphetamine dose, hyperthermia, seizures, and the blood-brain barrier.

@article{Bowyer2008BrainRN,
  title={Brain region-specific neurodegenerative profiles showing the relative importance of amphetamine dose, hyperthermia, seizures, and the blood-brain barrier.},
  author={John F. Bowyer and Monzy Thomas and Larry C. Schmued and S. Fatehyab Ali},
  journal={Annals of the New York Academy of Sciences},
  year={2008},
  volume={1139},
  pages={127-39}
}
Understanding the neurotoxic effects of acute high-dose exposures of laboratory animals to methamphetamine (METH) and amphetamine (AMPH) is of relevance to understanding the neurotoxicity incurred in humans from overdose or abuse of these substances. We present recent findings on the neurodegenerative effects of both a single high dose of 40 mg/kg and a 4-dose exposure to AMPH in the rat. Comparing these results with those we have previously observed in rodents exposed to either AMPH or METH… CONTINUE READING
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