Brain region specific modulation of ethanol-induced depression of GABAergic neurons in the brain reward system by the nicotine receptor antagonist mecamylamine.

@article{Adermark2014BrainRS,
  title={Brain region specific modulation of ethanol-induced depression of GABAergic neurons in the brain reward system by the nicotine receptor antagonist mecamylamine.},
  author={Louise Adermark and Bo S{\"o}derpalm and John Michael Burkhardt},
  journal={Alcohol},
  year={2014},
  volume={48 5},
  pages={
          455-61
        }
}
Involvement of Inhibitory Receptors in Modulating Dopamine Signaling and Synaptic Activity Following Acute Ethanol Exposure in Striatal Subregions.
TLDR
The current results show that changes in striatal dopamine output and synaptic activity induced by acute EtOH administration are modulated by inhibitory receptors in a subregion-specific manner.
An acetylcholine‐dopamine interaction in the nucleus accumbens and its involvement in ethanol's dopamine‐releasing effect
TLDR
The data presented in this study suggest that basal extracellular levels of DA within the nAc are not sustained by ACh, whereas accumbal CIN‐ACh is involved in mediating ethanol‐induced DA release.
Nicotine and alcohol: the role of midbrain dopaminergic neurons in drug reinforcement
TLDR
This review describes how nicotine and alcohol individually affect VTA DA neurons by examining how drug exposure alters the heterogeneous VTA microcircuit and network‐wide projections and addresses the remaining questions related to the circuit‐function specificity of the dopaminergic system in mediating nicotine/alcohol reinforcement and comorbidity.
Dopaminergic Regulation of Striatal Interneurons in Reward and Addiction: Focus on Alcohol
TLDR
The role of striatal interneurons in modulating striatal output during drug reward is reviewed, with special emphasis on alcohol.
Reward contingency gates selective cholinergic suppression of amygdala neurons
TLDR
Cholinergic effects are modulated by reward contingency in a target-specific manner to promote conditioned responding and constrain clinical goals of augmenting cholinergic function to improve neuropsychiatric symptoms.
The molecular mechanism underlying GABAergic dysfunction in nucleus accumbens of depression‐like behaviours in mice
TLDR
The results showed that the expression level of GAT‐3, Gad‐1 and VGAT mRNA and protein significantly decreased in the NAc tissue from CUMS‐induced depression‐like mice than that of control mice, which may reveal the molecular mechanisms for the decreased GABA concentrations.
The Effect of Embryonic Alcohol Exposure on Brain Function and Behavior in Zebrafish Strains
TLDR
It is found that mild alcohol exposure during development results in an increase in apoptosis and that these early responses result in long-lasting changes in neuronal markers and number of cells in specific brain areas, which will facilitate a better understanding of FASD.
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