Brain region specific actions of regulator of G protein signaling 4 oppose morphine reward and dependence but promote analgesia.

@article{Han2010BrainRS,
  title={Brain region specific actions of regulator of G protein signaling 4 oppose morphine reward and dependence but promote analgesia.},
  author={Ming-Hi Han and Willam Renthal and Robert H Ring and Zia Rahman and Kassi Psifogeorgou and David Howland and Shari G Birnbaum and Kathleen C. Young and Rachael Neve and Eric J Nestler and Venetia Zachariou},
  journal={Biological psychiatry},
  year={2010},
  volume={67 8},
  pages={761-9}
}
BACKGROUND Regulator of G protein signaling 4 (RGS4) is one of the smaller members of the RGS family of proteins, which are known to control signaling amplitude and duration via interactions with G protein alpha subunits or other signaling molecules. Earlier evidence suggests dynamic regulation of RGS4 levels in neuronal networks mediating actions of opiates and other drugs of abuse, but the consequences of RGS4 actions in vivo are largely unknown. METHODS In this study, we use constitutive… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 24 extracted citations

Similar Papers

Loading similar papers…