Brain purines in a genetic mouse model of Lesch-Nyhan disease.

  title={Brain purines in a genetic mouse model of Lesch-Nyhan disease.},
  author={H. A. Jinnah and Theodore Page and Theodore Friedmann},
  journal={Journal of neurochemistry},
  volume={60 6},
Mice carrying a mutation in the gene encoding the purine salvage enzyme hypoxanthine-guanine phosphoribosyltransferase (HPRT) have recently been produced to provide an animal model for Lesch-Nyhan disease. The current studies were conducted to characterize the consequences of the mutation on the expression of HPRT and to characterize potential changes in brain purine content in these mutants. Our results indicate that the mutant animals have no detectable HPRT-immunoreactive material on western… CONTINUE READING