Brain proton magnetic resonance spectroscopy (1H-MRS) in Alzheimer's disease: changes after treatment with xanomeline, an M1 selective cholinergic agonist.

@article{Satlin1997BrainPM,
  title={Brain proton magnetic resonance spectroscopy (1H-MRS) in Alzheimer's disease: changes after treatment with xanomeline, an M1 selective cholinergic agonist.},
  author={Andrew Satlin and Neil Bodick and Walter W. Offen and Perry F. Renshaw},
  journal={The American journal of psychiatry},
  year={1997},
  volume={154 10},
  pages={1459-61}
}
OBJECTIVE Higher than normal cellular levels of the phospholipid catabolic intermediate glycerophosphocholine have been found in postmortem brain tissue of persons with Alzheimer's disease. Proton magnetic resonance spectroscopy (1H-MRS) can detect a choline resonance that is largely due to glycerophosphocholine. The authors tested the hypothesis that… CONTINUE READING