Brain processing during mechanical hyperalgesia in complex regional pain syndrome: a functional MRI study

@article{Maihfner2005BrainPD,
  title={Brain processing during mechanical hyperalgesia in complex regional pain syndrome: a functional MRI study},
  author={Christian Maih{\"o}fner and Clemens Forster and Frank Birklein and Bernhard Neundörfer and Hermann O. Handwerker},
  journal={Pain},
  year={2005},
  volume={114},
  pages={93-103}
}
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218 Citations
Highly Influential Citations
4
Background Citations
60
Methods Citations
14
Results Citations
10

218 Citations

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Complex regional pain syndrome is associated with structural abnormalities in pain-related regions of the human brain.

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Functional Imaging of Central Nervous System Involvement in Complex Regional Pain Syndrome

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In complex regional pain syndrome (CRPS), functional imaging studies gave evidence for an important role of the central nervous system (CNS) in the pathogenesis of the disease, leading to an altered central processing of tactile and nociceptive stimuli and an altered cerebral organization of movement.

Brain activity associated with pain, hyperalgesia and allodynia: an ALE meta-analysis

The use of functional brain imaging techniques offers the possibility of uncovering the cerebral processing of the human pain experience. In recent years, many imaging studies have focused on…

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The fMRI findings showing the cortical reorganization in a patient with type 2 CRPS were compared and showed significantly increased abnormal cortical responses on the primary and secondary somatosensory areas and the distinct parietal association area on the contra-lateral side of the brain to the stimuli on the affected painful hand.

Cortical processing of mechanical hyperalgesia: A MEG study

Microstructural Abnormalities of the Secondary Motor Area Coordinating Sensory and Motor Functions in Patients with Complex Regional Pain Syndrome

TLDR
The findings suggest that the wide variety of symptoms encompassing the sensory and motor systems of patients with CRPS are associated with microstructural impairment of the secondary motor area, which receives sensory information and projects motor information.
...

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