Brain processing during mechanical hyperalgesia in complex regional pain syndrome: a functional MRI study

@article{Maihfner2005BrainPD,
  title={Brain processing during mechanical hyperalgesia in complex regional pain syndrome: a functional MRI study},
  author={Christian Maih{\"o}fner and Clemens Forster and Frank Birklein and Bernhard Neundörfer and Hermann O. Handwerker},
  journal={Pain},
  year={2005},
  volume={114},
  pages={93-103}
}
Mislocalization of tactile stimulation in patients with complex regional pain syndrome
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The occurrence of mislocalizations was correlated with a detailed psychophysical examination in which sensory, motor and autonomic symptoms were assessed and support the concept of pain–induced reorganization in the somatosensory system of CRPS patients.
The motor system shows adaptive changes in complex regional pain syndrome.
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The results of this study suggest that substantial adaptive changes within the central nervous system may contribute to motor symptoms in CRPS.
Functional imaging of allodynia in complex regional pain syndrome
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The pattern of cortical deactivation during allodynia may hint at a shift of activation from tonically active sensory systems, like visual and vestibular cortices, into somatosensory-related brain areas.
Functional Imaging of Central Nervous System Involvement in Complex Regional Pain Syndrome
TLDR
In complex regional pain syndrome (CRPS), functional imaging studies gave evidence for an important role of the central nervous system (CNS) in the pathogenesis of the disease, leading to an altered central processing of tactile and nociceptive stimuli and an altered cerebral organization of movement.
Brain activity associated with pain, hyperalgesia and allodynia: an ALE meta-analysis
The use of functional brain imaging techniques offers the possibility of uncovering the cerebral processing of the human pain experience. In recent years, many imaging studies have focused on
Functional MRI findings showing cortical reorganization in a patient with type 2 complex regional pain syndrome: A case report.
TLDR
The fMRI findings showing the cortical reorganization in a patient with type 2 CRPS were compared and showed significantly increased abnormal cortical responses on the primary and secondary somatosensory areas and the distinct parietal association area on the contra-lateral side of the brain to the stimuli on the affected painful hand.
Cortical processing of mechanical hyperalgesia: A MEG study
Microstructural Abnormalities of the Secondary Motor Area Coordinating Sensory and Motor Functions in Patients with Complex Regional Pain Syndrome
TLDR
The findings suggest that the wide variety of symptoms encompassing the sensory and motor systems of patients with CRPS are associated with microstructural impairment of the secondary motor area, which receives sensory information and projects motor information.
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This study highlights the importance of a cortical network comprising S1, PA, S2/insula and IFC in the processing of dynamic–mechanical allodynia in the human brain and demonstrates that the combined heat/capsaicin model can be used successfully in the exploration of brain processes underlying stimulus‐evoked pain.
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