Brain processing during mechanical hyperalgesia in complex regional pain syndrome: a functional MRI study

  title={Brain processing during mechanical hyperalgesia in complex regional pain syndrome: a functional MRI study},
  author={Christian Maih{\"o}fner and Clemens Forster and Frank Birklein and Bernhard Neundörfer and Hermann O. Handwerker},

Mislocalization of tactile stimulation in patients with complex regional pain syndrome

The occurrence of mislocalizations was correlated with a detailed psychophysical examination in which sensory, motor and autonomic symptoms were assessed and support the concept of pain–induced reorganization in the somatosensory system of CRPS patients.

The motor system shows adaptive changes in complex regional pain syndrome.

The results of this study suggest that substantial adaptive changes within the central nervous system may contribute to motor symptoms in CRPS.

Functional imaging of allodynia in complex regional pain syndrome

The pattern of cortical deactivation during allodynia may hint at a shift of activation from tonically active sensory systems, like visual and vestibular cortices, into somatosensory-related brain areas.

Functional Imaging of Central Nervous System Involvement in Complex Regional Pain Syndrome

In complex regional pain syndrome (CRPS), functional imaging studies gave evidence for an important role of the central nervous system (CNS) in the pathogenesis of the disease, leading to an altered central processing of tactile and nociceptive stimuli and an altered cerebral organization of movement.

Brain activity associated with pain, hyperalgesia and allodynia: an ALE meta-analysis

The use of functional brain imaging techniques offers the possibility of uncovering the cerebral processing of the human pain experience. In recent years, many imaging studies have focused on

Functional MRI findings showing cortical reorganization in a patient with type 2 complex regional pain syndrome: A case report.

The fMRI findings showing the cortical reorganization in a patient with type 2 CRPS were compared and showed significantly increased abnormal cortical responses on the primary and secondary somatosensory areas and the distinct parietal association area on the contra-lateral side of the brain to the stimuli on the affected painful hand.

Cortical processing of mechanical hyperalgesia: A MEG study

Microstructural Abnormalities of the Secondary Motor Area Coordinating Sensory and Motor Functions in Patients with Complex Regional Pain Syndrome

The findings suggest that the wide variety of symptoms encompassing the sensory and motor systems of patients with CRPS are associated with microstructural impairment of the secondary motor area, which receives sensory information and projects motor information.



Facilitated neurogenic inflammation in complex regional pain syndrome

Patterns of cortical reorganization in complex regional pain syndrome

This study showed reorganization of the S1 cortex contralateral to the CRPS affected side, and it appeared to be linked to complaints of neuropathic pain.

Altered central somatosensory processing in chronic pain patients with “hysterical” anesthesia

Diminished perception of innocuous and noxious stimuli is associated with altered activity in many parts of the somatosensory pathway or other supraspinal areas, and cortical findings indicate a neurobiological component for at least part of the symptoms in patients presenting with nondermatomal somatoensory deficits.

Brain processing of capsaicin-induced secondary hyperalgesia

Prefrontal activation is interpreted as a consequence of attention, cognitive evaluation, and planning of motor behavior in response to pain, and the lack of activation of the anterior cingulate contrasts with physiologic pain after C-nociceptor stimulation.

Complex regional pain syndrome is a disease of the central nervous system

Understanding why CRPS type I may develop after a trivial trauma, after a trauma being remote from the affected extremity exhibiting CRPS, and possibly after immobilization of an extremity is further understood.

Neural activation during experimental allodynia: a functional magnetic resonance imaging study

This study highlights the importance of a cortical network comprising S1, PA, S2/insula and IFC in the processing of dynamic–mechanical allodynia in the human brain and demonstrates that the combined heat/capsaicin model can be used successfully in the exploration of brain processes underlying stimulus‐evoked pain.

Neurological findings in complex regional pain syndromes--analysis of 145 cases.

The detailed knowledge of clinical features of CRPS could help physicians early to recognize the disease and thus to improve therapy outcome.