Brain plasticity: From pathophysiological mechanisms to therapeutic applications

@article{Duffau2006BrainPF,
  title={Brain plasticity: From pathophysiological mechanisms to therapeutic applications},
  author={H. Duffau},
  journal={Journal of Clinical Neuroscience},
  year={2006},
  volume={13},
  pages={885-897}
}
  • H. Duffau
  • Published 2006
  • Medicine
  • Journal of Clinical Neuroscience
Cerebral plasticity, which is the dynamic potential of the brain to reorganize itself during ontogeny, learning, or following damage, has been widely studied in the last decade, in vitro, in animals, and also in humans since the development of functional neuroimaging. In the first part of this review, the main hypotheses about the pathophysiological mechanisms underlying plasticity are presented. At a microscopic level, modulations of synaptic efficacy, unmasking of latent connections… Expand
Brain plasticity and tumors.
  • H. Duffau
  • Medicine
  • Advances and technical standards in neurosurgery
  • 2008
TLDR
Enhanced preoperative prediction of an individual's potential for reorganization might be integrated into surgical planning and preserving quality of life through tailored rehabilitation programmes to optimize functional recovery following resection of a brain tumor. Expand
Neuroplasticity: induction and modulation by external stimulation and pharmacological intervention
Neuroplasticity, the ability of the human brain to reorganize itself structurally and/or functionally, has been intensively studied in modern neuroscience research. The recent development of advancedExpand
Neuroplasticity: Insights from Patients Harboring Gliomas
TLDR
The utility and limitations of various investigative techniques, such as direct electrocortical stimulation (DES), functional magnetic resonance imaging (fMRI), corticocortical evoked potential (CCEP), and diffusion tensor imaging (DTI), are discussed. Expand
Brain Plasticity in Neurosurgery
TLDR
Individual mapping studies in patients with well-defined brain lesions not only enhance the outcome of operations but may provide a practical route to understanding, visualizing, and even modulating brain plasticity. Expand
Do children really recover better? Neurobehavioural plasticity after early brain insult.
TLDR
It is concluded that neither plasticity nor vulnerability theories are able to explain the range of functional outcomes from early brain insult, and where a child's outcome falls along a 'recovery continuum' depends on injury factors and environmental influences. Expand
Neural Plasticity After Acquired Brain Injury: Evidence from Functional Neuroimaging
TLDR
In this article, traumatic brain injury and stroke are used as examples in which neural plasticity plays an important role in recovery, and exciting future directions for the evaluation, diagnosis, and treatment of severe brain injury are explored. Expand
Physiology of repetitive transcranial magnetic stimulation of the human brain
TLDR
This review presents seven lines of evidence that strongly suggest a link between the aftereffects induced by rTMS and the induction of synaptic plasticity, and provides suggestions for future, innovating research, aiming to investigate both the local effects of rT MS on the synapse and the effects of RTMS on other, more global levels of brain organization. Expand
Functional MRI of Neural Plasticity and Drug Effect in the Brain
Recent advances in magnetic resonance imaging (MRI) have opened up new perspectives for understanding brain function and its plasticity after damage or even in the process of learning and memory.Expand
Brain Plasticity and the Enhancement of Brain Functioning
Neuroscience methods and knowledge base are evolving quickly and there is a growing understanding of brain plasticity. There is now growing empirical evidence for specific and disparate mechanisms ofExpand
Does post-lesional subcortical plasticity exist in the human brain?
  • H. Duffau
  • Psychology, Medicine
  • Neuroscience Research
  • 2009
TLDR
The aim is to study whether subcortical structures are able to actively reorganize by themselves (rewiring), or whether it is only a passive consequence of the cortical remapping, to show whether the capacity of anatomic rewiring actually exists in human brain. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 262 REFERENCES
Physiological consequences of morphologically detectable synaptic plasticity: potential uses for examining recovery following damage
TLDR
Evidence that the brain retains the capacity to modify its organization in response to demands, including demands resulting from learning, throughout the lifetime is surveyed. Expand
[Brain plasticity during development: physiological bases and functional MRI approach].
  • L. Hertz-Pannier
  • Medicine
  • Journal of neuroradiology. Journal de neuroradiologie
  • 1999
Brain functional MRI (fMRI) is a new tool for the study of the development of cognitive functions in healthy children ("natural plasticity"), as well as for the assessment of functionalExpand
Transcranial magnetic stimulation as a therapeutic tool in psychiatry: what do we know about the neurobiological mechanisms?
Potential therapeutic properties of repetitive transcranial magnetic stimulation (rTMS) have been suggested in several psychiatric disorders such as depression, mania, obsessive-compulsive disorder,Expand
Environmental influence on gene expression and recovery from cerebral ischemia.
TLDR
Gene expression for brain derived neurotrophic factor and Ca2+/calmodulin-dependent protein kinase II, two substances with potential role in brain plasticity, show different patterns in animals housed in standard and in enriched environment. Expand
Integrated technology for evaluation of brain function and neural plasticity.
TLDR
This multitechnology combined approach is at present the best way to test the presence and amount of plasticity phenomena underlying partial or total recovery of several functions, sensorimotor above all. Expand
Mechanisms and the Current State of Deep Brain Stimulation in Neuropsychiatry
TLDR
Deep brain stimulation precisely targets neuroanatomical targets deep within the brain that are proposed to be centrally involved in the pathophysiology of some neuropsychiatric illnesses, offering the advantages of reversibility and adjustability. Expand
Brain plasticity and stroke rehabilitation. The Willis lecture.
TLDR
Better knowledge of postischemic molecular and neurophysiological events, and close interaction between basic and applied research, will hopefully enable us to design rehabilitation strategies based on neurobiological principles in a not-too-distant future. Expand
Neuropharmacology of TBI-induced plasticity
TLDR
Although some drugs such as d-amphetamine have the potential to enhance recovery, others such as neuroleptics and other central dopamine receptor antagonists, benzodiazepines and the anti-convulsants phenytoin and phenobarbital may be detrimental. Expand
Cortical plasticity after stroke: implications for rehabilitation.
TLDR
Taking together with parallel studies of forced use in human stroke patients, it is likely that use of the impaired limb can influence adaptive reorganizational mechanisms in the intact cerebral cortex, and thus, promote functional recovery. Expand
Plasticity and behavior New genetic techniques to address multiple forms and functions
TLDR
Recently developed genetic techniques, specifically, inducible transgenic models, which now allow more precise manipulations in the study of the roles plasticity plays in learning and memory are discussed. Expand
...
1
2
3
4
5
...