Brain plasticity: From pathophysiological mechanisms to therapeutic applications

  title={Brain plasticity: From pathophysiological mechanisms to therapeutic applications},
  author={Hugues Duffau},
  journal={Journal of Clinical Neuroscience},
  • H. Duffau
  • Published 1 November 2006
  • Biology, Psychology, Medicine
  • Journal of Clinical Neuroscience

Brain plasticity and tumors.

  • H. Duffau
  • Medicine
    Advances and technical standards in neurosurgery
  • 2008
Enhanced preoperative prediction of an individual's potential for reorganization might be integrated into surgical planning and preserving quality of life through tailored rehabilitation programmes to optimize functional recovery following resection of a brain tumor.

Neuroplasticity: induction and modulation by external stimulation and pharmacological intervention

A gender difference of neuroplasticity induced by tDCS in humans is explored and it is found that bothDA and ACh enhance focal and suppress global excitability-enhancing plasticity, which supports the hypothesis that DA and A Ch focus specific synaptic inputs in neural networks in order to raise signal-to-noise ratio and thereby enhance information processing.

Neuroplasticity: Insights from Patients Harboring Gliomas

The utility and limitations of various investigative techniques, such as direct electrocortical stimulation (DES), functional magnetic resonance imaging (fMRI), corticocortical evoked potential (CCEP), and diffusion tensor imaging (DTI), are discussed.

Do children really recover better? Neurobehavioural plasticity after early brain insult.

It is concluded that neither plasticity nor vulnerability theories are able to explain the range of functional outcomes from early brain insult, and where a child's outcome falls along a 'recovery continuum' depends on injury factors and environmental influences.

Brain Plasticity in Neurosurgery

Individual mapping studies in patients with well-defined brain lesions not only enhance the outcome of operations but may provide a practical route to understanding, visualizing, and even modulating brain plasticity.

Neural Plasticity After Acquired Brain Injury: Evidence from Functional Neuroimaging

Functional MRI of Neural Plasticity and Drug Effect in the Brain

It is demonstrated the spatial memory network can be visualized in water maze trained animal and it is showed that synchrony rather than activity in the brain can be modulated by receptor targeted pharmaceuticals, which indicate a different drug mechanism.

Brain Plasticity and the Enhancement of Brain Functioning

It is important to understand that improved understanding of brain plasticity holds promise for effective treatment of diverse symptoms (physical, cognitive, psychological) and more accurate time frames for brain injury recovery.

Does post-lesional subcortical plasticity exist in the human brain?

  • H. Duffau
  • Psychology, Biology
    Neuroscience Research
  • 2009



[Brain plasticity during development: physiological bases and functional MRI approach].

  • L. Hertz-Pannier
  • Psychology, Biology
    Journal of neuroradiology. Journal de neuroradiologie
  • 1999
Brain functional MRI (fMRI) is a new tool for the study of the development of cognitive functions in healthy children ("natural plasticity"), as well as for the assessment of functional

Environmental influence on gene expression and recovery from cerebral ischemia.

Gene expression for brain derived neurotrophic factor and Ca2+/calmodulin-dependent protein kinase II, two substances with potential role in brain plasticity, show different patterns in animals housed in standard and in enriched environment.

Integrated technology for evaluation of brain function and neural plasticity.

Brain plasticity and stroke rehabilitation. The Willis lecture.

Better knowledge of postischemic molecular and neurophysiological events, and close interaction between basic and applied research, will hopefully enable us to design rehabilitation strategies based on neurobiological principles in a not-too-distant future.

Mechanisms and the Current State of Deep Brain Stimulation in Neuropsychiatry

Deep brain stimulation precisely targets neuroanatomical targets deep within the brain that are proposed to be centrally involved in the pathophysiology of some neuropsychiatric illnesses, offering the advantages of reversibility and adjustability.

Neuropharmacology of TBI-induced plasticity

Although some drugs such as d-amphetamine have the potential to enhance recovery, others such as neuroleptics and other central dopamine receptor antagonists, benzodiazepines and the anti-convulsants phenytoin and phenobarbital may be detrimental.

Cortical plasticity after stroke: implications for rehabilitation.

Taking together with parallel studies of forced use in human stroke patients, it is likely that use of the impaired limb can influence adaptive reorganizational mechanisms in the intact cerebral cortex, and thus, promote functional recovery.