Brain pH responses to sodium bicarbonate and Carbicarb during systemic acidosis.

@article{Shapiro1989BrainPR,
  title={Brain pH responses to sodium bicarbonate and Carbicarb during systemic acidosis.},
  author={Joseph Isaac Shapiro and Molly A. Whalen and R R Kucera and Neal B. Kindig and Giles F. Filley and Laurence K. Chan},
  journal={The American journal of physiology},
  year={1989},
  volume={256 5 Pt 2},
  pages={H1316-21}
}
Rats subjected to ammonium chloride-induced metabolic acidosis or respiratory acidosis caused by hypercapnia were given alkalinization therapy with either sodium bicarbonate or Carbicarb. Ammonium chloride induced dose-dependent systemic acidosis but did not affect intracellular brain pH. Hypercapnia caused dose-dependent systemic acidosis as well as decreases in intracellular brain pH. Sodium bicarbonate treatment resulted in systemic alkalinization and increases in arterial PCO2 in both… CONTINUE READING

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