Brain oxygen utilization is unchanged by hypoglycemia in normal humans: lactate, alanine, and leucine uptake are not sufficient to offset energy deficit.

@article{Lubow2006BrainOU,
  title={Brain oxygen utilization is unchanged by hypoglycemia in normal humans: lactate, alanine, and leucine uptake are not sufficient to offset energy deficit.},
  author={Jeffrey M Lubow and Ivan G Pi{\~n}{\'o}n and A. Avogaro and C. Cobelli and David M Treeson and Katherine Mandeville and G. Toffolo and P. Boyle},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2006},
  volume={290 1},
  pages={
          E149-E153
        }
}
During hypoglycemia, substrates other than glucose have been suggested to serve as alternate neural fuels. We evaluated brain uptake of endogenously produced lactate, alanine, and leucine at euglycemia and during insulin-induced hypoglycemia in 17 normal subjects. Cross-brain arteriovenous differences for plasma glucose, lactate, alanine, leucine, and oxygen content were quantitated. Cerebral blood flow (CBF) was measured by Fick methodology using N(2)O as the dilution indicator gas. Substrate… Expand
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