Brain opiate receptor concentrations are increased in adult spontaneously hypertensive rats.

@article{Martucci1979BrainOR,
  title={Brain opiate receptor concentrations are increased in adult spontaneously hypertensive rats.},
  author={Charles Martucci and Elliot F. Hahn},
  journal={Endocrine research communications},
  year={1979},
  volume={6 4},
  pages={291-7}
}
The saturable binding of 3H-naltrexone in the brains of eight week old spontaneously hypertensive rats (SHR) is about twice that measured in corresponding normotensive WKY rats. This increase is dependent on age since in three and four week old SHR and WKY rats no difference in binding is observed. Scatchard analysis of the saturation curves for the adult animals revealed that the change in binding is due to an increase in the number of binding sites and does not reflect a difference in binding… CONTINUE READING