Brain networks underlying perceptual habituation to repeated aversive visceral stimuli in patients with irritable bowel syndrome

@article{Labus2009BrainNU,
  title={Brain networks underlying perceptual habituation to repeated aversive visceral stimuli in patients with irritable bowel syndrome},
  author={Jennifer S. Labus and Bruce D. Naliboff and Steve M. Berman and Brandall Y. Suyenobu and Eduardo P. Vianna and Kirsten Tillisch and Emeran A. Mayer},
  journal={NeuroImage},
  year={2009},
  volume={47 3},
  pages={952-60}
}
Patients with irritable bowel syndrome (IBS) show decreased discomfort and pain thresholds to visceral stimuli, as well hypervigilance to gastrointestinal sensations, symptoms, and the context in which these visceral sensations and symptoms occur. Previous research demonstrated normalization of visceral hypersensitivity following repeated exposure to experimental rectal stimuli over a 12-month period that was associated with reduction in cortical regions functionally associated with attention… CONTINUE READING