Brain network alterations in Alzheimer's disease measured by eigenvector centrality in fMRI are related to cognition and CSF biomarkers.

@article{Binnewijzend2014BrainNA,
  title={Brain network alterations in Alzheimer's disease measured by eigenvector centrality in fMRI are related to cognition and CSF biomarkers.},
  author={Maja A. A. Binnewijzend and Sofie M. Adriaanse and Wiesje Maria van der Flier and Charlotte E Teunissen and Jan Casper de Munck and Cornelis J. Stam and Philip Scheltens and Bart N. M. van Berckel and Frederik Barkhof and Alle Meije Wink},
  journal={Human brain mapping},
  year={2014},
  volume={35 5},
  pages={2383-93}
}
Recent imaging studies have demonstrated functional brain network changes in patients with Alzheimer's disease (AD). Eigenvector centrality (EC) is a graph analytical measure that identifies prominent regions in the brain network hierarchy and detects localized differences between patient populations. This study used voxel-wise EC mapping (ECM) to analyze individual whole-brain resting-state functional magnetic resonance imaging (MRI) scans in 39 AD patients (age 67 ± 8) and 43 healthy controls… CONTINUE READING

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