Brain natriuretic peptide limits myocardial infarct size dependent of nitric oxide synthase in rats.

@article{Ren2007BrainNP,
  title={Brain natriuretic peptide limits myocardial infarct size dependent of nitric oxide synthase in rats.},
  author={Binhui Ren and Yi Shen and Hongtao Shao and Jianjun Qian and Haiwei Wu and Hua Jing},
  journal={Clinica chimica acta; international journal of clinical chemistry},
  year={2007},
  volume={377 1-2},
  pages={83-7}
}
BACKGROUND Brain natriuretic peptide (BNP) has recently been shown to have a cardioprotective effect in animal models of myocardial ischemia-reperfusion (I-R) injury. We hypothesized that exogenous BNP limits myocardial infarction on nitric oxide synthase pathway. METHODS A rat model of myocardial I-R injury was established by ligating the left descending coronary artery for 30 min and then reperfusing for 2 h. BNP was injected with different dose 5 min after the ligation and lasting for 145… CONTINUE READING

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